Description : POLYDOCANOL is a sterile, nonpyrogenic, and colorless to faintly greenish-yellow solution of polidocanol for intravenous use as a sclerosing agent.
The active ingredient, polidocanol is a non-ionic detergent, consisting of two components, a polar hydrophilic (dodecyl alcohol) and an apolar hydrophobic (polyethylene oxide) chain. Polidocanol has the following structural formula:
Each mL contains3 mg (0.3%) polidocanol in water for injection with 5% (v/v) ethanol at pH 6.5-8.0; disodium hydrogen phosphate dihydrate, potassium dihydrogen phosphate are added for pH adjustment.
ASKLEROL (polidocanol) is indicated to sclerose uncomplicated spider veins (varicose veins ≤ 1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. Asclera has not been studied in varicose veins more than 3 mm in diameter..
For spider veins (varicose veins ≤ 1 mm in diameter), use ASKLEROL 0.3%. For reticular veins (varicose veins 1 to 3 mm in diameter)..
Repeat treatments may be necessary if the extent of the varicose veins requires more than 10 mL. These treatments should be separated by 1 to 2 weeks.
Dosage Forms And Strengths
ASKLEROLis available as a 0.3% and 1% solution in 2 mL glass ampules.
Storage and Handling
ASKLEROL is supplied in single-use, preservative free ampules in 2amp s tray packed in an independent box.